iLab Organizer :: Biological Evaluation Shared Resource

Overview of Services

In cancer biology, mouse models play a crucial role in studying tumor invasion, metastasis, malignant transformation, and therapy responses. Key advancements in animal models for cancer biology include orthotopic models for metastasis, transgenic animals with developmental pathways to tumorigenesis, and state-of-the-art immunocompromised strains. Transplanted human xenografts remain a primary tool for molecular discovery and evaluation. Despite their limitations, xenograft mouse models have significantly contributed to cancer drug development over the past three decades and will continue to be foundational in the fight against cancer.

At the Purdue Center for Cancer Research (PCCR), a vast pipeline of potential new agents for diagnosing and treating cancer has emerged. Researchers need a productive and established facility for in vivo testing that can navigate the complexities of murine cancer models.

The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, in vivo mouse model selection, and experimental design in the evaluation of potential therapeutic agent.

If you are new to this core or need to discuss an experiment, please contact Bennett Elzey, Ph.D., Shared Resources Director, at belzey@purdue.edu.

Services and Pricing

Services Provided:

Xenograft and Syngeneic Models:

Subcutaneous, intraperitoneal, intracardiac, and intravenous tumor model implantation

Orthotopic Tumor Models:

Bladder, pancreas, prostate, kidney, bladder, bone, brain (intracranial), mammary fat pad, ovary.

PDX Models

Efficacy Studies:

Mouse weight
Tumor size is monitored by caliper measurements for subcutaneous models
in vivo imaging for orthotopic or disseminated models

Mice Toxicity Study, Chronic Toxicity Study, Maximum-Tolerated Dose (MTD), and Pharmacokinetic (PK) Studies

Drug Administration:

Intravenously (IV), intramuscularly (IM), intraperitoneally (IP), subcutaneously (SC), intratracheal instillation, by food and/or drinking water

In Vivo Imaging Studies:

AMI bioluminescence and fluorescence
Micro CT
Ultrasound

Euthanasia, Necropsy with Organ and Tissue Collection and Preservation of Tissues/Organs

Blood Collection

PDX Tumor Maintenance and Expansion

Cell Lines and tumor tissues (PDX)

Pricing:

Service	PCCR Member Rate	Internal non-PCCR Member Rate	CTSI members	External
Consultation	No Cost
Grant Writing	No Cost
Hourly Rate	$80.00	Contact us for rate
NRG mice (in-house breeding colony)	$70.00	Contact us for rate
Other mice	Prices vary depending on supplier

Study prices vary based on client needs. Please contact us for quote on study

Acknowledgement

“XXXX” data were acquired by the "XXX" facility supported by P30 CA023168

Getting Started

Purdue Users: New users: Click LOGIN and use your Purdue ID to register for an iLab account.
NON Purdue: individuals: Before you register, you must be assigned a Business Partner Number and given a PUID to register/login. Please contact Bennett Elzey, Ph.D. at belzey@purdue.edu. An email will be sent to you with your PUID and instructions on how to get registered.
Visit the iLab Help Site or Customer Help Manual for further guidance using iLab's Core Facility Services.

Leadership

Bennett Elzey, PH.D.

Shared Resources Director

Contacts

Name	Role	Phone	Email	Location
Bennet D Elzey	Director	(765)496-4249	belzey@purdue.edu	Hansen
Sandra Torregrosa-Allen	Laboratory Manager	(765)496-0212	storregr@purdue.edu	Hansen