Transgenic Mouse Core Facility

Transgenic Mouse Core Facility (TMCF)

The PCCR’s TMCF Shared Resource is a state-of-the-art facility that offers a large number of services to the Center membership, including the creation of transgenic and knock-out mouse and rat models for gain-of-function and loss-of-function experimental approaches to dissect transcriptional, signaling, and environmental influences on tumor initiation, progression and metastasis. Model systems based on transgenic and knock-in/knock-out strategies provide approaches that are developmentally, anatomically and physiologically relevant to human disease, and that can supplement traditional xenograft models for testing new anti-cancer therapies. Transgenic animal models provide valuable reagents for studying aspects of cancer cell biology, ranging from the regulatory mechanisms governing gene expression patterns to cell-cell interactions, cell cycle control and regulation of signal transduction pathways. Additionally, these models have been instrumental in dissecting the importance of immune cells and stromal infiltrates to tumor progression, and have helped to identify novel cancer stem cell lineages that are often resistant to conventional chemotherapeutics.

 

If you are new to this core or need to discuss a construct, please contact Judy Hallett, Shared Resources Manager at halletje@purdue.edu

 

Acknowledgement

“XXXX” data were acquired by the "XXX" facility supported by P30 CA023168

Getting Started

  • Purdue Users: New users: Click LOGIN and use your Purdue ID to register for an iLab account.
  • NON Purdue Users: Before you register, you must be assigned a Business Partner Number and given a PUID to register/login. Please contact Judy Hallett at halletje@purdue.edu.  An email will be sent to you with your PUID and instructions on how to get registered.
  • Visit the iLab Help Site or Customer Help Manual for further guidance using iLab's Core Facility Services.

Links and Resources

  1. TMCF Website

Services

Name Description